Evaluating the Role of Genetic Markers in Prostate Cancer Progression: A Multiethnic Cohort Experience
Final rept. 4 Sep 2007-3 Sep 2011
M D ANDERSON CANCER CENTER HOUSTON TX
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Most prostate cancerPCa research has focused on risk, little is known about predictors of progression and even less about how these factors differ by ethnicityrace. There are strong racial disparities in mortality with African-Americans twice as likely to die from PCa comparedto Caucasians very little data are available in Hispanics. Our goal was to identify markers of PCa progression in a multiethnic cohort773 Caucasians, 361 African-Americans 246 Mexican-Americans. Medical records for all participants have been abstracted, and we have updated vital status using the National Death Index. Using DNA extracted from archived specimens, we utilized a genome wide association study approach to identify polymorphisms associated with PCa progression this approach has lead to the identification of different polymorphisms to be relevant in Caucasians vs. African- Americans. These results may offer insight into racialethnic differences in PCa progression and may be used to develop racespecific models for PCa progression.
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