Accession Number:

ADA555332

Title:

Transcriptional Analysis of Rat Piriform Cortex Following Exposure to the Organophosphonate Anticholinesterase Sarin and Induction of Seizures

Descriptive Note:

Open literature

Corporate Author:

ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD

Report Date:

2011-01-01

Pagination or Media Count:

1.0

Abstract:

Organophosphorus nerve agent irreversibly inhibit acetylcholinesterase, causing a toxic buildup of acetylcholine at muscarinic and nicotinic receptors. Current medical countermeasureres to nerve agent intoxication increase survival if administered within a short period of time following exposure but may not fully prevent neurological damage. Therefore, there is a need to discover drug treatments that are effective when administered after the onset of seizures and secondary responses that lead to brain injury.

Subject Categories:

  • Organic Chemistry
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE