Transcriptional Analysis of Rat Piriform Cortex Following Exposure to the Organophosphonate Anticholinesterase Sarin and Induction of Seizures
ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
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Organophosphorus nerve agent irreversibly inhibit acetylcholinesterase, causing a toxic buildup of acetylcholine at muscarinic and nicotinic receptors. Current medical countermeasureres to nerve agent intoxication increase survival if administered within a short period of time following exposure but may not fully prevent neurological damage. Therefore, there is a need to discover drug treatments that are effective when administered after the onset of seizures and secondary responses that lead to brain injury.
- Organic Chemistry
- Chemical, Biological and Radiological Warfare