Accession Number:

ADA555248

Title:

Methodology Report for H2SModel

Descriptive Note:

Technical rept. Oct 2009-Aug 2011

Corporate Author:

APPLIED RESEARCH ASSOCIATES INC ARLINGTON VA

Report Date:

2012-01-01

Pagination or Media Count:

31.0

Abstract:

Hydrogen sulfide is similar in pathophysiology to cyanide in that it binds to mitochondrial cytochrome oxidase. By blocking oxidative respiration at the cellular level its effects are most evident in tissues with high metabolic demand such as the central nervous system, cardiovascular, and respiratory systems. The onset of signs and symptoms is rapid. Hydrogen sulfide also has local irritant effects, particularly upon the nose and membranes of the upper respiratory tract and the eyes. Physiological manifestations of H2S exposure may be quantified as a time-dependent severity vector described as increased time required to perform tasks owing to H2S-induced performance decrements as well as lethality. The model uses the time integral of agent concentration to calculate an internal dose, then determines the severity vector based on the dose. Outcome probability can be estimated as the time course till the casualty returns to duty, or else dies. Although H2S has not knowingly been used in warfare, it is a toxic industrial chemicaltoxic industrial material that could be used as a terrorist agent.

Subject Categories:

  • Anatomy and Physiology
  • Inorganic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE