A Partnership Training Program: Studying Targeted Drug Delivery Using Nanoparticles In Breast Cancer Diagnosis and Therapy
Annual summary rept. 15 Sep 2010-14 Sep 2011
HOWARD UNIV WASHINGTON DC
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In the first year of this training grant, 10 faculty members, and 7 graduate and 1 undergraduate students from 6 departments at the Howard University have been trained using nanoparticles as targeted drug delivery vehicles for cancer diagnosis and therapy. A total of 16 seminars and webinars, plus 6 workshops and symposia in cancer, molecular imaging and nanomedicine have been offered. The trainees have also received hands-on training in imaging and analytical instrumentations. The two research projects have started and progressed well. We have constructed and characterized cationic liposomes encapsulated MRI contrast agents for improving the sensitivity and specificity of breast cancer imaging. We studied the stability of nanoparticles in light of potential toxicity of nanoparticles used in humans. We have also used A-dmDT390-scfbDbPSMA, a single chain Fv fragments of antibody with diphtheria toxin, to demonstrate that a nano sized immunotoxin can be used for targeted delivery of toxin to the cancer cells and also can be used as an imaging reporter. The Howard University Nanomedicine Core was established and it has supported 10 research projects. The Nanomedicine Core has become a synergy center drawing multidisciplinary research collaborations using nanotechnology for targeted drug delivery and improving breast cancer diagnosis and therapy.
- Personnel Management and Labor Relations
- Medicine and Medical Research