Corneal Protection for Burn Patients
Annual rept. 1 Jul 2010-30 Jun 2011
MASSACHUSETTS GENERAL HOSPITAL BOSTON
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The overall goal of this research is to preserve vision of patients recovering from severe facial burns by providing an improved method to reduce development of corneal defects, inflammation, infection and opacification. Scope To further improve and understand the properties of the degradation-resistant crosslinked amniotic membranes for treating cornea of burn patients that were produced in Year 1. Major findings Established that 2 and 3 layer crosslinked amniotic membrane composites are more resistant to enzymatic degradation and thus expected to be more lasting on patients eyes, that chemical and photo-initiated crosslinking of amnion proteins are associated with the loss of TGF- , a cytokine tightly associated with crosslinked proteins in amnion, and that crosslinked amnion can be photobonded to cornea ex vivo thereby providing an alternative for suturing these degradation-resistant membranes to the ocular surface. An amnion-covered contact lens was constructed and photobonded to ex vivo cornea as an approach to supplying hydration to burn patients eyes.
- Anatomy and Physiology
- Medicine and Medical Research