Are Blast Brain Injuries Fundamentally Different Than Traditional Experimental Models of TBI?
Final rept. 1 Jul 2009-30 Jun 2011
UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES
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We compared acute neurophysiological changes in rats following a blast-type TBI induced by a shock tube with more traditional models of TBI, i.e., midline fluid percussion PERCUSSION and controlled cortical impact brain injuries. Currently, insufficient data exists which compares the physiological brain changes induced by a blast-type injuries to those generated by more traditional animal models of TBI. We hypothesized in this proposal that brain damage from a blast-type injury BLAST may be very similar to those induced by a PERC injury model but fundamentally different than penetrating and ballistic-type brain injuries modeled by a pneumatic piston. We first documented neurophysiological and behavioral changes in rats following graded levels of PERCUSSION injury, which has been submitted for rapid publication in Neurosurgery Focus see Appendix. In the second year, approved as a no-cost extension , we are analyzing the data for BLAST injuries and comparing where on the severity scale, BLAST brain injuries fall when compared to PERCUSSON injuries of graded intensities.
- Medicine and Medical Research