Noninvasive Subharmonic Pressure Estimation for Monitoring Breast Cancer Response to Neoadjuvant Therapy
Annual rept. 1 Sep 2010-31 Aug 2011
THOMAS JEFFERSON UNIV PHILADELPHIA PA
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Neoadjuvant chemotherapy is currently the standard of care for locally advanced breast cancer LABC. Monitoring tumor response is advantageous for patients. This project aims at establishing noninvasive monitoring of neoadjuvant chemotherapy in the breast using subharmonic aided pressure estimation SHAPE to estimate the interstitial fluid pressure IFP in LABC. New in vitro experiments with the ultrasound contrast agent Definity have showed an inverse linear relationship between the change in subharmonic amplitude and hydrostatic pressure r2 0.63 - 0.95, p 0.01 over the pressure range associated with breast tumors 0 50 mmHg. Moreover, software for analyzing RF data from a Sonix RP scanner to produce SHAPE pressure estimates has been successfully optimized and published. In vivoproof of concept for SHAPE as a noninvasive monitor of IFP r2 0.67 - 0.96, p 0.01 has been provided based on a swine model. The work on in vivo SHAPE measurements of IFPwas selected for the final of the American Institute of Ultrasound in Medicine AIUM 2011 Young Investigator Award for V. G. Halldorsdottir and was awarded FIRST place out of 90 abstracts submitted for this competition.
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- Stress Physiology