Accession Number:

ADA555029

Title:

Genes Associated with Food Allergy and Eosinophilic Esophagitis

Descriptive Note:

Annual rept. 1 Sep 2010-31 Aug 2011

Corporate Author:

CALIFORNIA UNIV SAN DIEGO LA JOLLA

Personal Author(s):

Report Date:

2011-09-01

Pagination or Media Count:

5.0

Abstract:

The ingestion of food antigens plays an essential role in the development of eosinophilic esophagitis EE as total removal of dietary antigens by using an amino acid based oral formula improves clinical symptoms and esophageal histology in 98 of patients with EE within a month. EE is thought to be mediated by both IgE and non-IgE mediated food allergy. In this study we are particularly interested in identifying genes in EE linked to a significant complication of EE namely esophageal stricture formation. This study focuses on increasing our understanding of two genes TGF-b and acidic chitinase associated with remodeling and stricture formation in the esophagus in EE. The importance of TGF-b and acidic chitinase to the development of egg induced remodeling of the esophagus is being studied in a mouse model in which either TGF-b signaling or acidic chitinase activity is neutralized. In the 6 months since the mouse protocol was approved we have completed breeding of Smad3 deficient mice and investigated whether TGF-b is important in egg induced remodeling in a mouse model of EE in Smad-3 deficient mice deficient in TGF-b signaling compared to WT mice. Results will be available in 6 months.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Food, Food Service and Nutrition

Distribution Statement:

APPROVED FOR PUBLIC RELEASE