Csk Homologous Kinase, a Potential Regulator of CXCR4-Medicated Breast Cancer Cell Metastasis
Final rept. 1 Aug 2009-31 Jul 2011
PITTSBURGH UNIV PA
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Current therapy still fails to kill migrating metastasizing breast cancer cells. Metastatic migration of breast cancer cells is an immediate concern for breast cancer patients as it remains the actual cause of morbidity and mortality. The expression of chemokine receptors, CXCR4, is tightly correlated with the metastatic properties of breast cancer cells. CHK showed its ability to regulate CXCR4 mRNA, supporting our hypothesis that CHK signaling axis may regulate the metastatic migration of breast cancer cells. Especially, wild-type SH2 domain, SH2-R147A and SH2-G129A displayed their differential capacity to regulate CXCR4 expression in breast cancer cells. These results suggest the possibility that the differential binding capacity of CHK SH2 domain to ErbB2 may play a role in CXCR4-mediated breast cancer metastasis. While it still needs further studies to check if CHK gene is mutated in metastatic breast cancer cells, a correlation between CHK and CXCR4 protein was observed in metastatic breast cancer specimens n28.
- Medicine and Medical Research