Accession Number:

ADA553111

Title:

Regulation of Cell Migration in Breast Cancer

Descriptive Note:

Annual summary 1 Apr 2010-31 Mar 2011

Corporate Author:

HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE BETHESDA MD

Personal Author(s):

Report Date:

2011-04-01

Pagination or Media Count:

13.0

Abstract:

Cell migration is an essential cellular process and deregulation of this process may result in serious consequences such as tumor metastasis. Numerous studies have demonstrated that the IPP complex is linked to cell adhesion and cell migration. Our lab has found that Rsu-1 binds to the IPP complex through PINCH1 5 and the absence of either Rsu-1 or PINCH proteins results in a change in epithelial cell migration. In addition, the levels, the forms and the subcellular localization of Rsu-1 and 1PP proteins are altered in breast cancer cells compared to non-tumorigenic mammary epithelial cells. particular, the Rsu-1 variants contribute to breast cancer cell migration. Therefore, it is my hypothesis that Rsu-1 splice variants contribute to cell migration by functioning as a regulator of essential migration processes. In addition, the presence ofRsu-1 splice variants may enhance migration in tumorigenic mammary epithelial cell lines. Since focal adhesion formation and stabilit, G-protein signaling and actin polymerization are fundamental in the process of cell migration, the information that we gather relevant to these processes will further om understanding of the role of the IPP complex and Rsu-1 in the regulation of cell migration. This research is proposed to elucidate the mechanistic role of Rsu-1 in breast cancer cell migration.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE