Accession Number:

ADA552450

Title:

Reconstructing the Prostate Cancer Transcriptional Regulatory Network

Descriptive Note:

Annual summary, 1 Jun 2009-30 Sep 2010

Corporate Author:

LELAND STANFORD JUNIOR UNIV CA

Personal Author(s):

Report Date:

2010-09-01

Pagination or Media Count:

36.0

Abstract:

This award has enabled the development of computational methods to analyze and integrate diverse prostate cancer genomic datasets. We have successfully applied our newly-developed methods to a prostate cancer dataset, resulting in the identification of genes that may play a causal role in prostate tumor metastasis. Our analysis of prostate tumor DNA copy number data has also uncovered a potentially novel tumor suppressor gene associated with clinically-indolent prostate cancer. This finding may represent a much-needed biomarker capable of distinguishing indolent versus aggressive disease, and may lead to novel strategies for patient management.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE