Reconstructing the Prostate Cancer Transcriptional Regulatory Network
Annual summary, 1 Jun 2009-30 Sep 2010
LELAND STANFORD JUNIOR UNIV CA
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This award has enabled the development of computational methods to analyze and integrate diverse prostate cancer genomic datasets. We have successfully applied our newly-developed methods to a prostate cancer dataset, resulting in the identification of genes that may play a causal role in prostate tumor metastasis. Our analysis of prostate tumor DNA copy number data has also uncovered a potentially novel tumor suppressor gene associated with clinically-indolent prostate cancer. This finding may represent a much-needed biomarker capable of distinguishing indolent versus aggressive disease, and may lead to novel strategies for patient management.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research