Accession Number:

ADA552313

Title:

Volunteer Challenge With Enterotoxigenic Escherichia coli That Express Intestinal Colonization Factor Fimbriae CS17 and CS19

Descriptive Note:

Journal article

Corporate Author:

NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD ENTERIC DISEASES DEPT

Report Date:

2011-07-01

Pagination or Media Count:

6.0

Abstract:

Human challenges with enterotoxigenic Escherichia coli ETEC have broadened our understanding of this important enteropathogen. We report findings from the first challenge studies using ETEC-expressing colonization factor fimbria CSI7 and CSI9. LSN03-016011A LT, CS17 elicited a dosedependent effect, with the upper dose 6 X 10exp 9 organisms causing diarrhea in 88 of recipients. WS0115A LTSTp, CSI9 also showed a dose response, with a 44 diarrhea rate at 9 X 10exp 9 organisms. Both strains elicited homologous antifimbrial and anti-L T antibody seroconversion. These studies establish the relative pathogenicity of ETEC expressing newer class 5 fimbriae and suggest suitability of the LTCS17-ETEC challenge model for interventional trials.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE