Accession Number:

ADA552118

Title:

IL-6 Receptor Isoforms and Ovarian Cancer Progression

Descriptive Note:

Annual rept. 15 Sep 2009-14 Sep 2010

Corporate Author:

CINCINNATI UNIV OH

Personal Author(s):

• Drew, Angela F.

Report Date:

2010-10-01

Pagination or Media Count:

26.0

Abstract:

During the research period, we have successfully achieved our goals of demonstrating IL6R in the ovarian tumor microenvironment and identifying the differentially-spliced isoform as being prominent. In addition, we have demonstrated an important relationship between IL6R expression and the earliest steps in metastasis of ovarian cancer. Both tumor cells and host myeloid cells contribute to IL6R expression within a tumor, thus providing multiple targets for intervening in ovarian cancer metastasis. Our continuing studies will identify the mechanism by which IL6R influences metastasis and opportunities for preventing or reducing this outcome.

Descriptors:

• *OVARIAN CANCER
• CELLS(BIOLOGY)
• GROWTH(PHYSIOLOGY)
• INFLAMMATION
• METASTASIS
• NEOPLASMS

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE