Accession Number:

ADA552079

Title:

Intravenous Perfluorocarbon After Onset of Decompression Sickness Decreases Mortality in 20-kg Swine

Descriptive Note:

Journal article

Corporate Author:

NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD

Report Date:

2010-06-01

Pagination or Media Count:

6.0

Abstract:

Decompression sickness DCS occurs when bubbles form due to pressure decreases with severity ranging from trivial to fatal. Standard treatment requires a hyperbaric chamber, not likely to be available at remote sites or during a disabled submarine escape or rescue. Alternative non-recompressive treatments are needed. Intravenous administration of emulsified perfluorocarbons PFCs enhances oxygen delivery to, and inert gas removal from, tissues. Swine studies show PFCs administered with supplemental oxygen before symptom onset can decrease DCS incidence. We used a swine model to test whether PFC plus supplemental oxygen could improve outcome when infused after DCS symptom onset.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE