Accession Number:

ADA551987

Title:

In Vivo Cerebral Blood Flow Autoregulation Studies Using Rheoencephalography

Descriptive Note:

Conference paper

Corporate Author:

WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD

Report Date:

2010-01-01

Pagination or Media Count:

5.0

Abstract:

Acute management of patients with traumatic brainblast injury is a challenge. To minimize secondary injury and improve outcome, it is critical to detect neurological deterioration early, when it is potentially reversible. One potential monitoring method is cerebral electrical impedance rheoencephalography-REG because of its non-invasiveness and good time resolution. Reported here are the results of cerebral blood flow CBF manipulations comparing electroencephalogram EEG with REG both intra-cerebral and measuring with surface and skull REG electrodes. Our hypothesis was that REG would reflect spreading depression and CBF autoregulation. Animal experiments were performed using one rat four trials with intracerebral electrodes, monkeys n8, with surface electrodes and pigs n 24 pigs with skull electrodes 57 trials, 19 types of liposomes. Challenges included intracranial pressure ICP elevation, liposome infusion, and hemorrhage. Data were stored on a PC and evaluated off line. CBF autoregulation was evaluated both by visual inspection and by a Matlab script. These studies confirmed that REG reflects CBF autoregulation and that REG is useful for detecting spreading depression SD, vasospasm and the lower limit of CBF autoregulation. These findings have clinical relevance for use in noninvasive neuro-monitoring in the neurosurgery intensive care and during transportation of patients with brain injury.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE