Accession Number:

ADA551890

Title:

The Effects of Bisphenol A (BPA) on ErbB2 Positive Breast Cancer

Descriptive Note:

Annual summary 1 Nov 2008-31 Oct 2009

Corporate Author:

ALABAMA UNIV IN BIRMINGHAM

Personal Author(s):

Report Date:

2009-11-01

Pagination or Media Count:

8.0

Abstract:

The purpose of this grant was to investigate the ability of BPA, when administered orally, to alter tumorigenesis in a transgenic mouse model that over-expresses the erbB2 proto-oncogene erbB2-tg. BPA did not function in a traditional, linear dose-responsive manner to induce tumorigenesis. Our data indicate that the environmentally relevant concentrations of BPA BPA 2.5 and BPA 25 function in a different manner than the regulatory-based concentrations of BPA BPA 250 and BPA 2500. Only the environmentally relevant BPA doses significantly accelerated mammary tumorigenesis, decreasing tumor latency and increasing tumor multiplicity, burden, and the rate of metastasis. Prior to tumor formation, all BPA doses significantly increased the rate of cell proliferation in the mammary gland, but only the regulatory-based doses increased the rate of apoptosis. Because environmentally relevant concentrations of BPA failed to increase apoptosis to counter the increased rate of proliferation, the ratio of proliferation-to-apoptosis was altered. This ratio best predicted the tumorigenic response of erbB2-tg mice to each dose of BPA studied.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE