Accession Number:

ADA551724

Title:

Evaluation of Coagulation Stages of Hemorrhaged Swine: Comparison of Thromboelastography and Rotational Elastometry

Descriptive Note:

Journal article

Corporate Author:

NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD

Report Date:

2010-01-01

Pagination or Media Count:

9.0

Abstract:

Thromboelastography TEG or rotational thromboelastometry ROTEM assesses blood viscoelastic properties and clotting kinetics that can be measured by Haemoscope TEG and Pentapharm ROTEM devices using slightly different methodologies. These devices were compared by measuring blood samples associated with various degrees of coagulopathy. Blood samples, collected from swine undergoing three types of severe injury and resuscitation protocol resulting in normal, hypercoagulopathy, and hypocoagulopathy, were assessed with TEG or ROTEM before the surgical procedures, and after Injury, fluid resuscitation, and simulated hospital phase. Standard clotting parameters were compared by Students t-test at a significance of a P value less than 0.05. Regression analysis indicated a positive correlation between TEG and ROTEM for reaction time R, clotting rate K, and maximum amplitude M8 parameters. With samples of normal coagulation, R 440 136 vs. 391 73 s, K 99 39 vs. 81 20 s, and M8 74 4 vs. 69 5 mm were higher, whereas cd 68 8 vs. 75 3 mm was lower with TEG than ROTEM, respectively a P value is less than 0.05. The magnitude of changes from baseline In hypercoagulable or hypocoagulable samples due to level of injury was equivalent with TEG and ROTEM indicating comparable use of the instruments. However, when samples were extremely hypocoagulopathic due to resuscitation fluid, the TEG values could not be readily determined. Overall, TEG readings were higher than ROTEM readings this disparity between the two instruments was attenuated with hypercoaguable samples. Both devices yielded similar Information regarding the status of coagulation related to trauma. Because of operating characteristics, the same instrument should be used for monitoring the same patient or study.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE