Accession Number:

ADA551701

Title:

Endoscopic Ultrasound Does Not Accurately Stage Early Adenocarcinoma or High-Grade Dysplasia of the Esophagus

Descriptive Note:

Journal article

Corporate Author:

NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD

Personal Author(s):

• Young, Patrick E.
• Gentry, Andrew B.
• Acosta, Ruben D.
• Greenwald, Bruce D.
• Riddle, Mark

Report Date:

2010-01-01

Pagination or Media Count:

6.0

Abstract:

Patients with esophageal high grade dysplasia or mucosal esophageal cancer can he successfully treated hy endoscopy. We performed a systematic review of the literature to determine whether endoscopic ultrasound EUS correctly predicts the T-stage of early esophageal cancers, compared with pathology specimens obtained by using endoscopic mucosal resection EMR or surgery. METHODS Standard systematic review methods were used w perform reference searches, determine eligibility, abstract data, and analyze data. When possible, individual patient-level data were abstracted, in addition to publication- level aggregate data. RESULTS Twelve studies had sufficient information to abstract and review for quality 8 had individual patient-level data n 132. Compared with surgical or EMR pathology staging, EUS had T-stage concordance of 65, including all studies n 12, but only 56 concordance when limited to individual patient-level data. Factors such as initial biopsy pathology high-grade dysplasia vs early-stage cancer did not appear to affect the concordance of staging between EUS and EMRsurgical staging. CONCLUSIONS BUS is not sufficiently accurate in determining the T -stage of high-grade dysplasias or superficial adenocarcinomas other means of staging, such as EMR, should be used.

Descriptors:

• *CANCER
• *DYSPLASIA
• *ESOPHAGUS
• AGGREGATES(MATERIALS)
• MUCOUS MEMBRANES
• PATHOLOGY
• PATIENTS
• STAGING

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE