Accession Number:

ADA551697

Title:

Combat Wound Initiative Program

Descriptive Note:

Journal article

Corporate Author:

WALTER REED ARMY MEDICAL CENTER WASHINGTON DC DEPT OF SURGERY

Report Date:

2010-07-01

Pagination or Media Count:

8.0

Abstract:

The Combat Wound Initiative CWI program is a collaborative, multidisciplinary, and interservice public-private partnership that provides personalized, state-of-the-art, and complex wound care via targeted clinical and translational research. The CWI uses a bench-to-bedside approach to translational research, including the rapid development of a human extracorporeal shock wave therapy ESWT study in complex wounds after establishing the potential efficacy, biologic mechanisms and safety of this treatment modality in a murine model. Additional clinical trials include the prospective use of clinical data, serum and wound biomarkers, and wound gene expression profiles to predict wound healingfailure and additional clinical patient outcomes following combat-related trauma. These clinical research data are analyzed using machine-based learning algorithms to develop predictive treatment models to guide clinical decision-making. Future CWI directions include additional clinical trials and study centers and the refinement and deployment of our genetically driven, personalized medicine initiative to provide patient-specific care across multiple medical disciplines, with an emphasis on combat casualty care.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE