Accession Number:

ADA550968

Title:

Contrast Agents for Micro-Computed Tomography of Microdamage in Bone

Descriptive Note:

Final rept. 1 Jan 2006-31 Dec 2010

Corporate Author:

NOTRE DAME UNIV IN

Personal Author(s):

Report Date:

2011-01-01

Pagination or Media Count:

133.0

Abstract:

Novel methods were investigated for detecting damaged bone tissue using contrast-enhanced micro-computed tomography micro-CT. The presence, spatial location, and accumulation of fatigue microdamage in machined human cortical bone specimens and whole rat femora was non-destructively detected in vitro after labeling by barium sulfate precipitation, and was validated by conventional histology. Micro-CT enabled non-destructive imaging and provided 3-D spatial information, which are not possible using conventional histology. These new methods are immediately useful for in vitro scientific studies investigating the etiology of fatigue and fragility fractures in bone. Functionalized Au NPs were demonstrated to enable targeted delivery and labeled microdamage was detected using synchrotron radiation computed tomography with absorption edge subtraction. Therefore, the results of this study suggest that the ambitious goal of non-invasive in vivo imaging of microdamage in bone could be feasible with improvements in commercial scientific and clinical CT instruments

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Computer Programming and Software

Distribution Statement:

APPROVED FOR PUBLIC RELEASE