Accession Number:

ADA550955

Title:

Biofunctionalized Zinc Oxide Field Effect Transistors for Selective Sensing of Riboflavin With Current Modulation

Descriptive Note:

Journal article

Corporate Author:

AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH SENSORS DIRECTORATE

Report Date:

2011-06-27

Pagination or Media Count:

12.0

Abstract:

Zinc oxide field effect transistors ZnO-FET, covalently functionalized with single stranded DNA aptamers, provide a highly selective platform for label-free small molecule sensing. The nanostructured surface morphology of ZnO provides high sensitivity and room temperature deposition allows for a wide array of substrate types. Herein we demonstrate the selective detection of riboflavin down to the pM level in aqueous solution using the negative electrical current response of the ZnO-FET by covalently attaching a riboflavin binding aptamer to the surface. The response of the biofunctionalized ZnO-FET was tuned by attaching a redox tag ferrocene to the 3 terminus of the aptamer, resulting in positive current modulation upon exposure to riboflavin down to pM levels.

Subject Categories:

  • Biochemistry
  • Inorganic Chemistry
  • Electrical and Electronic Equipment

Distribution Statement:

APPROVED FOR PUBLIC RELEASE