The Role of Fatty Acid Metabolism in Estrogen Receptor-Negative Breast Cancer
Annual rept. 15 Aug 2010-14 Aug 2011
NEW YORK UNIV NY
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The goal of this proposal was to determine whether there were differences in fatty acid activation between estrogen receptor positive ER and receptor negative ER- breast cancer. As a result of support provided by this award, we have been able to expand this investigation to include other hormone receptor biomarkers, and have determined that expression of long-chain fatty acyl-CoA synthetase 4 ACSL4 is negatively correlated with expression of ER, androgen receptor AR, progesterone receptor PR and human epidermal growth factor receptor 2 HER2, and in fact functions as a biomarker of quadruple negative breast cancer QNBC. In addition, we have demonstrated that expression of ACSL4 is able to mediate estrogen resistance. We are currently assessing the utility of using ACSL4 as a biomarker in the prediction of hormone resistance.
- Anatomy and Physiology
- Medicine and Medical Research