Medial Prefrontal Cortex and HPA Axis Roles in Generation of PTSD-Like Symptoms in SPS Model
Revised annual rept. 1 Sep 2009-31 Aug 2010
MICHIGAN UNIV ANN ARBOR
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In this report, we will demonstrate that we have a replicated some pilot findings presented in the initial grant application, b completed some of the proposed research in specific aims 2 and 3, and c started research proposed in specific aim 4. We have been unable to replicate our initial SPS effect on social avoidance and freezing induced by trimethlylthiazoline i.e. predator odor, but are still interested in exploring SPS effects on social behavior specific aim 2 and regulation of defense behavior specific aim 3, because we believe these are relevant to the etiology of post traumatic stress disorder. Because we now have to use different animal paradigms to address our specific aims, we have altered our statement of work to reflect this. To date, the research from this grant application has resulted in two peer reviewed journal publications, nine poster presentations, and four manuscripts that are currently being prepared for submission.
- Medicine and Medical Research