Acute and Short-Term Inhalation Toxicity Study of FT Fuel
Interim rept. Jan 2008-Sep 2010
THE HAMMER INSTITUTES FOR HEALTH SCIENCES RESEARCH TRIANGLE PARK NC
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FT or S-8 jet fuel is a synthetic organic mixture produced using the Fischer-Tropsch FT process that transforms natural gas to liquid hydrocarbons. Studies are being conducted to thoroughly evaluate the toxicity of FT jet fuel. First, an acute inhalation toxicity limit test was conducted FT jet fuel with additives was administered via inhalation exposure to rats once for 4 hours at the maximum specified concentration 2000 mgm3. No lethality or adverse clinical signs were demonstrated. In the second study, FT jet fuel, with JP-8 additive package, was administered as an aerosol and vapor mixture via repeated inhalation exposure to rats for 6 hours per day, 5 days per week over 2 weeks at concentrations of 0, 500, 1000 and 2000 mgm3. A slight but significant effect on bodyweight was observed in males exposed to the high 2000 mgm3 concentration. In the nasal tissues at the intermediate 1000 mgm3 and high 2000 mgm3 concentrations, minimal to mild olfactory epithelial degeneration was observed, increasing with the higher concentration, and with deeper penetration into the nose. In the lung, foci of inflammatory cell infiltration were observed in all high and some intermediate concentration exposure group animals. FT jet fuel is similar to or less toxic than JP-8 in equivalent tests. In addition, micronucleus induction was tested FT jet fuel does not induce micronuclei, indicating that the fuel is not genotoxic. A hydrocarbon fingerprint analysis of the aerosol and vapor phase of the delivered test fuel was performed.
- Anatomy and Physiology