A Genome-Wide Breast Cancer Scan in African Americans
Annual rept. 1 Jun 2010-31 May 2011
UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES
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Genome-wide association studies GWAS of breast cancer have been completed among populations of European ancestry, and several regions have been identified that appear to contribute susceptibility to this cancer. However, recent data suggest that not all risk alleles for common cancers will be revealed by studies limited to Whites of European ancestry, and that similar efforts in other racial and ethnic populations will be needed to identify the full spectrum of common risk alleles that contribute to disease risk in the population. To identify genetic risk alleles for breast cancer risk among African American women, we are performing a well-powered whole-genome association scan. For this project, we have established a collaborative network of investigators whose careers have been dedicated to studying breast cancer in minority populations. They have contributed samples and covariates from each of their respective studies to identify genetic variants that contribute to the risk of breast cancer in this minority population. We have completed a GWAS of 1.1 SNPs in 3000 African American breast cancer cases and 2700 controls. With these data, we have validated and improved upon markers of risk at the known breast cancer risk regions that better characterize their contribution to breast cancer risk in women of African ancestry. In collaboration with GWAS in populations of European ancestry, we also have revealed a novel risk locus for estrogen receptor negative breast cancer. In this report, we present results for two specific analyses 1 fine-mapping of the known breast cancer risk loci, and 2 a meta-analyses of GWAS for estrogen receptor negative breast cancer.
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- Genetic Engineering and Molecular Biology
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