Accession Number:

ADA550332

Title:

Transrectal Near-Infrared Optical Tomography for Prostate Imaging

Descriptive Note:

Final rept. 1 Mar 2007-28 Feb 2011

Corporate Author:

OKLAHOMA STATE UNIV STILLWATER

Personal Author(s):

Report Date:

2011-03-01

Pagination or Media Count:

269.0

Abstract:

Purpose to explore the technology of trans-rectal near-infrared NIR optical tomography that may benefit accurate, selective prostate biopsy. Updated scope to develop a TRUS-coupled optical tomography technology for imaging prostate cancer in canine model. Major findings 1 the onset of a prostate tumor was detected earlier by the researched technique than by using TRUS alone 2 the changes of blood concentration of a rapidly growing prostate tumor were quantified 3 the regression of a TVT mass in a canine prostate was detected as having a gradually decreasing oxygen level and a gradually increasing region of reduced oxygenation in the inner area of the tumor foci, coupled with intermittently increased total hemoglobin in the periphery of the mass 4 a cystic lesion also presented with slightly increased total hemoglobin with oxygen-reduction in the periphery of the lesion, and the slightly increased total hemoglobin was found by histopathology to be related to intralesional hemorrhage. Significance and impact These discoveries are expected to have impact on more accurate imaging guidance for targeted prostate biopsy, and monitoring treatment of locally advanced disease.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE