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Pathological Fingerprints, Systems Biology and Biomarkers of Blast Brain Injury

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Annual rept. 15 May 2009-14 May 2010

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We compared the effects of primary blast overpressure exposure of controlled duration, peak pressure, and transmitted impulse with brain injury by a severe blast load accompanied with strong head acceleration. The off-axis rat positioning avoided strong head acceleration due to the blast generator venting gas impulse, and reproduced primary blast with different mechanisms. sICAM, L-selectin, and E-selectin accumulated substantially in rat blood 24 hours after the blast and persisted for 14 days post-blast. Serum matrix metalloproteinases MMP exhibited a similar profile. Nerve growth factor beta-NGF in blood was significantly elevated within the first week post-blast and showed the most pronounced changes when the total animal body was subjected to blast waves. Resistin accumulated in rat blood 7 days after blast followed by a gradual decline. Neuropeptide Orexin A content showed a drastic rise at 24 hours after a blast that targeted the total body, followed by a gradual decline. In contrast, a blast wave targeting only the animals head caused a gradual raise of Orexin through 30 days post-exposure. For all biomarkers, the detected levels rose in all the setups studied. Nevertheless, the most significant and persistent serum changes were observed when the total animal body was subjected to a blast wave compared to setups in which only the animals head was targeted. Proteomic profiling of novel biomarkers has been performed and the results are being analyzed.

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  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research
  • Weapons Effects (Biological)

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