Accession Number:

ADA547285

Title:

Drug and Vaccine evaluation in the Human Aotus Plasmodium falciparum Model

Descriptive Note:

Annual rept. 1 Apr 2010-30 Apr 2011

Corporate Author:

PROMED TRADING S A MIAMI FL

Personal Author(s):

Report Date:

2011-05-01

Pagination or Media Count:

18.0

Abstract:

Next generation quinoline methanol NGQM lead analog 8SF5MQ WR 319689 when administered to Aotus monkeys infected with Plasmodium falciparum FVO orally at 6.25 mgkg cleared and recrudesce but at 2.1 mgkg had no effect over parasitemia. In contrast, mefloquine at 6.25 mgkg cleared and cured but at 2.1 mgkg only suppressed. Additionally, we were able to cryopreserved Aotus blood at high density parasitemias 50 x 1000 x microL for both Plasmodium vivax AMRU-1 and P. vivax SAL-1 parasites that will be used at WRAIR for in vitro culture experiments. In another series of experiments, WR621308 at 65 mkg suppressed parasitemia in Aotus infected with P. falciparum FVO but toxic adverse effects observed in one animal stopped the experiment at a higher dose 130 mgkg.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE