Roles of SGK Isoform Signaling in Breast Cancer Migration and Invasion
Annual summary rept. 15 Mar 2010-14 Mar 2011
HARVARD COLL CAMBRIDGE MA
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14. ABSTRACT My experiments indicate that Serum and Glucocorticoid regulated Kinase SGK proteins facilitate breast cancer invasive migration, a critical step for ultimate cancer metastasis to other organs. The activation of SGK during cellular stress conditions, such as low oxygen found within a tumor, makes this data increasingly imperative for therapeutics. The research shown here demonstrates SGK loss in highly mestatic breast cancer cell lines causes an invasive migration defect. Conversely, the overexpression of SGK isoforms in breast cancer cell lines causes an enhancement of invasive migration. These discoveries are helping to elucidate new mechanisms that can be targeted for more specific and successful therapies to block breast cancer metastasis. Known targets of SGK proteins are being examined for their contribution to the metastatic properties of breast cancer cells. These studies will determine the importance of SGK proteins as putative therapeutic targets for breast cancer motility.
- Medicine and Medical Research