Triterpenoidal Saponins: Bioactive Secondary Metabolites from Zygophyllum coccineum
AGRICULTURAL RESEARCH SERVICE UNIVERSITY MS NATURAL PRODUCTS UTILIZATION RESEARCH UNIT
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Phytochemical investigation of the aerial parts of Zygophyllum coccineum L. led to the isolation of nine ursane-type triterpene saponins, including the new one zygophylloside S, together with a known flavonoid glycoside and a sterol glycoside. The isolated compounds were tested for antifungal activity against several important plant pathogens and for insecticidal activity against two important mosquito species. Among the isolated compounds 1, 3, 5, 6, and 9 showed 32-77 fungal growth inhibition at a concentration of 30 microns against Phomopsis viticola. Compound 9 showed 90 and 80 mosquitocidal activity at 3.1 micrograms0.5 microlitters against Aedes aegypti and Culex quinquefasciatus, respectively.