Identification of ATF5-Interacting, SH3-Containing Proteins in Breast Cancer Cells
Annual rept. 1 Aug 2009-31 Jul 2010
PENNSYLVANIA STATE UNIV HERSHEY
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Growing evidence suggests that ATF5, a member of the ATFCREB family of transcription factors, is a cancer-specific cell survival factor 1-3. ATF5 is highly expressed in breast carcinomas and several other types of cancer cells interference of ATF5 function in those cells causes cell death. Surprisingly, similar interference of ATF5 function in normal or non-cancer breast cells does not affect their survival 1, 2. Consistent with a required role for ATF5 in survival of cancer cells, ATF5 is down-regulated in a number of cancer cells in response to trophic withdrawal, which induces cell death of those cells. Moreover, overexpression of ATF5 blocks such death 3, 4. The mechanism underlying ATF5-regulated cellular functions is unknown. The overarching goal for this research is to identify the proteins that interact with ATF5 and that impact on ATF5s cancer-specific cell survival function. The purpose of this research is to understand how ATF5 acts as a cancer-specific cell survival factor in breast cancer cells and use this information to selectively destroy breast cancer.
- Medicine and Medical Research