Accession Number:

ADA543744

Title:

Sympathetic Nerves in Breast Cancer: Angiogenesis and Antiangiogenic Therapy

Descriptive Note:

Annual rept. 1 Feb 2010-31 Jan 2011

Corporate Author:

ROCHESTER UNIV NY

Personal Author(s):

Report Date:

2011-02-01

Pagination or Media Count:

15.0

Abstract:

We have demonstrated sympathetic tyrosine hydroxylase-positive TH nerve fibers innervating breast tumors growing in the murine mammary fat pad. To study the role of the sympathetic nervous system in breast tumor progression, we used two approaches 1 6-hydroxydopamine 6-OHDA to destroy sympathetic nerves and 2 desipramine to increase tumor NE concentration. 6-OHDA treatment reduced 4T1 tumor NE concentration by 60, demonstrating that tumor NE is derived primarily from sympathetic nerve fibers. With sympathetic denervation, tumor weight and IL-6 concentration were reduced. Chronic desipramine treatment increased tumor NE, but it elicited only a small, transient increase in tumor growth. The relatively small magnitude of the treatment effects suggest that homeostatic mechanisms compensate for altered NE availability.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE