Accession Number:

ADA543741

Title:

Multidisciplinary Analysis of Cyclophilin A Function in Human Breast Cancer

Descriptive Note:

Annual summary 1 Mar 2008-28 Feb 2011

Corporate Author:

NORTHWESTERN UNIV EVANSTON IL

Personal Author(s):

Report Date:

2011-03-01

Pagination or Media Count:

31.0

Abstract:

The goal of this project was to understand how cyclophilin A CypA regulates the prolactin receptor PRLr signaling. The data have demonstrated that CypA, serving as a molecular switch via its peptidyl-prolyl isomerase PPI activity, binds to and regulates the function of the PRLr. Furthermore, point mutagenesis analysis has implied that a single prolyl imide bond Pro-334 within the X-Box motif of intracellular domain of the PRLr is most likely responsible for the observed effects of CypA on the PRLr signaling. Finally, we have conducted several proof-of-concept studies that may lead to novel anti-breast cancer agents.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE