Multidisciplinary Analysis of Cyclophilin A Function in Human Breast Cancer
Annual summary 1 Mar 2008-28 Feb 2011
NORTHWESTERN UNIV EVANSTON IL
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The goal of this project was to understand how cyclophilin A CypA regulates the prolactin receptor PRLr signaling. The data have demonstrated that CypA, serving as a molecular switch via its peptidyl-prolyl isomerase PPI activity, binds to and regulates the function of the PRLr. Furthermore, point mutagenesis analysis has implied that a single prolyl imide bond Pro-334 within the X-Box motif of intracellular domain of the PRLr is most likely responsible for the observed effects of CypA on the PRLr signaling. Finally, we have conducted several proof-of-concept studies that may lead to novel anti-breast cancer agents.
- Medicine and Medical Research