Accession Number:

ADA542728

Title:

The Isolation and Characterization of Human Prostate Cancer Stem Cells

Descriptive Note:

Annual summary rept. 29 Jan 2010-28 Jan 2011

Corporate Author:

METHODIST HOSPITAL HOUSTON TX

Personal Author(s):

• Palappattu, Ganesh

Report Date:

2011-02-01

Pagination or Media Count:

19.0

Abstract:

The overall objective of this proposal is to develop a durable cure for lethal prostate cancer through the elucidation of the role of cancer stem cells in the pathogenesis of the disease. During the past year, we have made the following significant findingsobservations i employing a specific feeder layer rSVM, human prostate cancer xenograft cells from 3D structures we have termed glandoids, ii glandoids appear to be clonal and form tumors in vivo that recapitulate the parent xenograft and iii readily obtaining rSVM for in vitro cultures is challenging. We continue to optimize and validate our in vitro model of prostate cancer initiation to facilitate cancer stem cell discovery as well as drug targeting.

Descriptors:

• *PROSTATE CANCER
• *PATHOGENESIS
• *STEM CELLS
• DRUGS
• FEEDING
• CULTURES(BIOLOGY)
• TARGETING
• IN VITRO ANALYSIS
• DISEASES
• IN VIVO ANALYSIS

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE