Seamless Integration of Detection and Therapy for Breast Cancer using Targeted Engineered Nanoparticles
Final rept. 15 May 2003-14 May 2008
RICE UNIV HOUSTON TX
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This is a final cumulative report on the efforts of our team of researchers from Rice University and M. D. Anderson Cancer Center, in the DoD funded CDMRP award. The overall goal of the research was to develop an integrated diagnostic imaging and if needed therapy of breast cancers. We have demonstrated bioconjugation techniques to target the tumors by attaching antibodies and phage display ligand proteins to nanoparticles and studying the efficiency of nanoparticle attachment to cancer cells. We have demonstrated in mouse tumor models a number of diagnostic imaging modalities. The first molecular signature of cancer cells using surface enhanced Raman scattering was demonstrated. Finally we have optimized the size of nanoshell and demonstrated that it can be used both for diagnostic imaging and photothermal therapy as needed. In addition to meeting all the goals outlined in the original proposal, the research has lead to FDA approval for clinical trials for photothermal therapy of cancers. Numerous research laboratories have also started investigating nanoshell based cancer therapies.
- Anatomy and Physiology
- Medicine and Medical Research