Accession Number:

ADA540966

Title:

The Effects of rhBMP-2 Used for Spinal Fusion on Spinal Cord Pathology After Traumatic Injury

Descriptive Note:

Doctoral thesis

Corporate Author:

UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD F EDWARD HEBERT SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

2009-07-29

Pagination or Media Count:

126.0

Abstract:

Recombinant human bone morphogenetic protein-2 rhBMP-2 is a promising new therapeutic for spinal fusion procedures. Currently, rhBMP-2 is used off-label for spinal fusion in cases where there is concomitant spinal cord injury SCI, yet little is known about the direct effects of rhBMP-2 on the recovery from a SCI. We therefore performed a series of studies in rats to determine whether rhBMP-2, used for spinal fusion, could penetrate the injured spinal cord. Additionally, we sought to determine whether the use of rhBMP-2 led to morphologic changes within the injured spinal cord that may alter functional recovery from SCI.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE