The Effects of rhBMP-2 Used for Spinal Fusion on Spinal Cord Pathology After Traumatic Injury
UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD F EDWARD HEBERT SCHOOL OF MEDICINE
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Recombinant human bone morphogenetic protein-2 rhBMP-2 is a promising new therapeutic for spinal fusion procedures. Currently, rhBMP-2 is used off-label for spinal fusion in cases where there is concomitant spinal cord injury SCI, yet little is known about the direct effects of rhBMP-2 on the recovery from a SCI. We therefore performed a series of studies in rats to determine whether rhBMP-2, used for spinal fusion, could penetrate the injured spinal cord. Additionally, we sought to determine whether the use of rhBMP-2 led to morphologic changes within the injured spinal cord that may alter functional recovery from SCI.
- Anatomy and Physiology
- Medicine and Medical Research