Accession Number:

ADA539581

Title:

Impact of Using a High Surface Area Solid Phase Micro Extraction Device and Fast Gas Chromatography Heating Rates in the Sampling and Analysis of Trace Level Chemical Warfare Agents and CWA-Like Compounds

Descriptive Note:

Doctoral thesis

Corporate Author:

UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD F EDWARD HEBERT SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

2009-09-21

Pagination or Media Count:

95.0

Abstract:

In the event of a toxic chemical release, such as an incident involving chemical warfare agent compounds, rapid and accurate response is needed to mitigate harm to the public and to emergency responders. The ability to perform rapid air sampling and subsequent fast separation and analysis of the chemical compounds using a fieldable laboratory-quality analytical instrument in order to properly characterize the chemical threat would provide an increased level of awareness and safety. This research discusses the results of applying a newly developed dynamic air sampling technique, known as High-Surface Area Solid Phase Micro Extraction HSA-SPME, in the sampling and analysis of chemical warfare agent surrogate and degradation compounds. Use of this device at high sample flow rates 4 L min-1 exhibits increased extraction efficiency in terms of mass per unit time relative to traditionally used emergency response detection methods, which is beneficial for decision making and minimizing time in a contaminated environment in a field response scenario when time is of the essence. Use of a tandem HSA-SPME method, in which two devices are joined in series and the sorbent surface area is doubled, permits low detection limits 1 ppbv by GCMS with short sampling times 10-15 s. The speed, sensitivity and ease-of-use are demonstrated in comparison with a laboratory accepted standard chemical pre-concentration module.

Subject Categories:

  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE