Accession Number:

ADA539483

Title:

Protective Role of PI3-kinase/Akt/eNOS Signaling in Mechanical Stress Through Inhibition of p38 Mitogen-Activated Protein Kinase in Mouse Lung

Descriptive Note:

Journal article

Corporate Author:

ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD

Report Date:

2010-01-01

Pagination or Media Count:

10.0

Abstract:

Acute lung injury ALI is a complex syndrome marked by increased vascular permeability resulting in tissue edema and profound hypoxial1,2. Mechanical ventilation MV is often a necessary treatment for respiratory failure and a supportive measure in critically ill patients. However, it is well known that ventilation with high tidal volume HVT MV or pressure may be harmful, causing damage to previously healthy lungs or worsening already injured ones. This is especially the case for permeability whereby exacting mechanical stress on various components of the respiratory system can lead to ventilation associated lung injury VALI. We performed the study described herein in an effort to elucidate the underlying mechanisms of VALI and investigate potential therapies against VALI.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE