Evaluating the Role of Genetic Markers in Prostate Cancer Progression: A Multi-Ethnic Cohort Experience
Annual rept. 4 Sep 2009-3 Sep 2010
M D ANDERSON CANCER CENTER HOUSTON TX
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Most prostate cancerPCa research has focused on risk, little is known about predictors of progression and even less about how these factors differ by ethnicityrace. There are strong racial disparities in mortality with African-Americans twice as likely to die from PCa compared to Caucasians very little data are available in Hispanics. Our goal is to identify markers of PCa progression in a multiethnic cohort 773 Caucasians, 361 African-Americans and 246 Mexican-Americans. Medical records for all participants have been abstracted, and we are updating vital status using the National Death Index. We are multiplexing the genotyping assays to optimize the utilization of our archived specimens, and all DNA extractions have been completed. Our research may help explain ethnicracial disparities in PCa progression and provide direction towards eliminating these disparities and may guide future studies to develop ethnicracial specific interventions to improve outcome in the most common cancer in American men.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research