Accession Number:

ADA537829

Title:

Consistent Safety and Infectivity in Sporozoite Challenge Model of Plasmodium vivax in Malaria-Naive Human Volunteers

Descriptive Note:

Journal article

Corporate Author:

NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD MALARIA PROGRAM

Report Date:

2011-02-01

Pagination or Media Count:

10.0

Abstract:

A safe and reproducible Plasmodium vivax infectious challenge method is required to evaluate the efficacy of malaria vaccine candidates. Seventeen healthy Duffy and five Duffy - subjects were randomly allocated into three A-C groups and were exposed to the bites of 2-4 Anopheles albimanus mosquitoes infected with Plasmodium vivax derived from three donors. Duffy - subjects were included as controls for each group. Clinical manifestations of malaria and parasitemia were monitored beginning 7 days post-challenge. All Duffy volunteers developed patent malaria infection within 16 days after challenge. Prepatent period determined by thick smear, was longer for Group A median 14.5 d than for Groups B and C median 10 deach. Infected volunteers recovered rapidly after treatment with no serious adverse events. The bite of as low as two P. vivax-infected mosquitoes provides safe and reliable infections in malaria-naive volunteers, suitable for assessing antimalarial and vaccine efficacy trials.

Subject Categories:

  • Ecology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE