Accession Number:

ADA537802

Title:

The Effect of Airway Pressure Release Ventilation on Pulmonary Catheter Readings: Specifically Pulmonary Capillary Wedge Pressure in a Swine Model

Descriptive Note:

Journal article

Corporate Author:

BROOKE ARMY MEDICAL CENTER FORT SAM HOUSTON TX

Report Date:

2011-01-01

Pagination or Media Count:

6.0

Abstract:

Airway pressure release ventilation APRV is a mode of mechanical ventilation that theoretically believed to improve cardiac output by lowering right atrial pressure. However, hemodynamic parameters have never been formally assessed. Methods. Seven healthy swine were intubated and sedated. A baseline assessment of conventional ventilation assist control and positive end-expiratory pressure PEEP of 5 cm H2O was initiated. Ventilator mode was changed to APRV with incremental elevations of CPAP-high from 10 to 35 cm H2O. After a 3-to-5-minute stabilization period, measurements of hemodynamic parameters PCWP, LAP, and CVP were recorded at each level of APRV pressure settings. Results. Increasing CPAP caused increased PCWP and LAP measurements above their baseline values. Mean PCWP and LAP were linearly related LAP 0.66PCWP 4.5 cm H2O, R2 0.674, and P .001 over a wide range of high and low CPAP values during APRV. With return to conventional ventilation PCWP and LAP returned to their baseline values. Conclusion. PCWP is an accurate measurement of LAP during APRV over variable levels of CPAP. However, PCWP and LAP may not be accurate measurements of volume when CPAP is utilized.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE