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Interactions Between Vitamin D and Breast Cancer

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Final rept. 1 Sep 2007-30 Jun 2010

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This is a study of vitamin D therapy of women with breast cancer BCa in the neoadjuvant period. The goal of the study is to determine whether vitamin D changes the expression of important target genes that may predict BCa prognosis. Thus far we have recruited 48 patients of the planned total of 50 subjects. Several subjects are not included in this report since they have not yet had their surgery or we have not yet received their biopsy or surgical specimens. These data will eventually be added to the current analysis. The women were stratified according to their circulating vitamin D status serum 25OHD concentration receiving daily doses of vitamin D3 of 2000 IU, 4000 IU or 6000 IU or no therapy. We have analyzed the biopsy samples pre-intervention and compared results with the surgical specimens post-intervention to determine whether dietary vitamin D supplements can regulate the gene expression profile in the BCa cells and normal cells. The goal is to determine whether vitamin D deficiency is associated with a poor prognosis gene profile and whether vitamin D intervention converts the profile toward a more normal profile of gene expression, perhaps representing a better prognosis.

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  • Biochemistry
  • Medicine and Medical Research

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