Accession Number:

ADA537270

Title:

Mathematical Model that Describes the Transition from Thermal Photochemical Damage in Retinal Pigment Epithelial Cell Culture

Descriptive Note:

Journal article

Corporate Author:

TASC INC BROOKS CITY-BASE TX

Report Date:

2011-02-01

Pagination or Media Count:

4.0

Abstract:

We propose a rate process model for describing photochemical damage to retinal cells by short wavelength laser exposures. The rate equation for photochemical damage contains a positive rate that is temperature independent,and a negative quenching rate that is temperature dependent. Using the traditional Arrhenius integral to describe thermal damage, we derive damage threshold doses for both thermal and photochemical mechanisms, and show that the model accounts for the sharp transition from thermal to photochemical damage thresholds that have recently been observed in an in-vitro retinal model.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE