Neuroinflammatory Pathobiology in Gulf War Illness: Characterization With an Animal Model
Annual rept. 1 Aug 2009-31 Jul 2010
ILLINOIS UNIV AT CHICAGO
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Gulf War Illness GWI is a multi-symptom disorder with features characteristic of sickness behavior, a normal manifestation of an inflammatory response due to infection or injury, findings suggestive of a heightened or chronic neuroimmuneneuroinflammatory disorder. Our overarching hypothesis is that exposure to GWI-relevant compounds lead to enhanced andor prolonged expression of neuroinflammatory mediators in the brain. Our overall objective is to establish a neuroinflammatory model of GWI-related exposures, to define the contribution of high physiological stress, and to assess the potential for current pharmacotherapy to ameliorate these effects. However, after lengthy discussion on how to set up a fiscal relationship between the performing organization UIC and collaborators at the CDC, USAMRMC contracting officials required that a CRADA be established. Due to the extended period necessary to put this agreement into place, work on the project has just begun.
- Medicine and Medical Research