Telomerase as an Androgen Receptor-Regulated Target in Selenium Chemoprevention of Prostate Cancer
Annual summary rept. 1 May 2009-30 Apr 2010
TULANE UNIV NEW ORLEANS LA
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The present is to investigate telomerase as a potential target of AR signaling suppression by selenium. We found that combination of selenium and bicalutamide produced a robust downregulation of androgen receptor AR signaling and telomerase activity. Furthermore, apoptosis induction by the two agents is more significant compared to single treatment. Our findings thus indicate that selenium in combination with anti-androgen could represent a viable approach to improve the therapeutic outcome of androgen deprivation therapy. We also found that wild-type and mutant AR responses differentially to androgen under normoxia condition. However, in hypoxia condition, androgen up-regulates hTERT expression in both wild-type AR expressing cells and mutant AR expressing cells. Selenium is able to inhibit androgen-induced hTERT expression under hypoxia condition.
- Medicine and Medical Research