Accession Number:

ADA535502

Title:

IgG Responses to Tissue-Associated Antigens as Biomarkers of Immunological Treatment Efficacy

Descriptive Note:

Journal article

Corporate Author:

WISCONSIN UNIV-MADISON COMPREHENSIVE CANCER CENTER

Report Date:

2011-01-01

Pagination or Media Count:

11.0

Abstract:

We previously demonstrated that IgG responses to a panel of 126 prostate tissue-associated antigens are common in patients with prostate cancer. In the current report we questioned whether changes in IgG responses to this panel might be used as a measure of immune response, and potentially antigen spread, following prostate cancer-directed immune-active therapies. Sera were obtained from prostate cancer patients prior to and three months following treatment with androgen deprivation therapy n 34, a poxviral vaccine n 31, and a DNA vaccine n 21. Changes in IgG responses to individual antigens were identified by phage immunoblot. Patterns of IgG recognition following three months of treatment were evaluated using a machine-learned Bayesian Belief Network ML-BBN. We found that different antigens were recognized following androgen deprivation compared with vaccine therapies. While the number of clinical responders was low in the vaccine-treated populations, we demonstrate that ML-BBN can be used to develop potentially predictive models.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE