Novel Targeting Approach for Breast Cancer Gene Therapy
Final rept. 1 Sep 2008-31 Aug 2010
TEXAS A AND M UNIV COLLEGE STATION HEALTH SCIENCE CENTER
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Impaired balance between pro-apoptotic and anti-apoptotic molecules is common in cancer cells, including breast cancer, and it plays an important role in tumor initiation and progression. Proapoptotic gene therapy aims at enhancing the capacity of tumor cells to undergo apoptosis and renders the tumors sensitive to classical anticancer drugs and radiotherapy. We developed a novel therapeutic strategy that combines both targeted gene p53 delivery using sigma-receptor ligand-conjugated PAMAM dendrimers, followed by chemotherapy using doxorubicin.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research