Genetically Modified Porcine Skin Grafts for Treatment of Severe Burn Injuries
Annual rept. 1 Jul 2009-30 Jun 2010
MASSACHUSETTS GENERAL HOSPITAL BOSTON
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The most significant research findings in this time period include the fact that we have demonstrated that our genetically-modified pigskin grafts will perform as well human cadaveric allogeneic skin grafts as a temporary biologic cover for severe burn injuries for war-fighters. Our xenoskin transplants from pig to baboons have confirmed that our genetically-modified pigskin grafts last as long as baboon allograft skin, are not damaged by freezing, and are effective at treating full-thickness skin injuries typically seen in burn injuries sustained in combat. In addition, a short course of immunosuppression may enhance the efficacy of these grafts. Finally, our in vitro analysis has suggested a number of immunologic targets that may improve this approach in particular and xenotransplantation in general.
- Medicine and Medical Research