Targeted Therapies For Myeloma and Metastatic Bone Cancers
Annual rept. 18 Jan 2008-17 May 2009
SOUTHWEST RESEARCH INST SAN ANTONIO TX
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Developed methods to radiolabel polymer nanoparticles to our knowledge, this is the first time this has been accomplished. Quantified functional groups available for ligand conjugation using OPA amino reagent. Developed alternative assay to confirm affinity of bone-targeting nanoparticles to hydroxyapatite substrates. Demonstrated in vitro stability of radiolabeled nanoparticles. Successfully transferred our nanoparticle preparation protocols to another facility to support in vivo biodistribution studies. Started in vivo biodistribution studies to validate ability of our radiolabeled nanoparticles to be imaged for up to 48 hours and further confirming our protocol methods to study bone-targeting nanoparticle biodistribution via radio-imaging.
- Medicine and Medical Research