Accession Number:

ADA535181

Title:

Aspirin-Exacerbated Respiratory Disease: Evaluation and Management

Descriptive Note:

Journal article

Corporate Author:

NAVAL MEDICAL CENTER PORTSMOUTH VA

Personal Author(s):

Report Date:

2011-01-01

Pagination or Media Count:

9.0

Abstract:

The clinical syndrome of aspirin-exacerbated respiratory disease AERD is a condition where inhibition of cyclooxygenase-1 COX-1 induces attacks of upper and lower airway reactions, including rhinorrhea and varying degrees of bronchospasm and laryngospasm. Although the reaction is not IgEmediated, patients can also present with anaphylactic hypersensitivity reactions, including hypotension, after exposure to COX-1 inhibiting drugs. All patients with AERD have underlying nasal polyps and intractable sinus disease which may be difficult to treat with standard medical and surgical interventions. This review article focuses on the management of AERD patients with a particular emphasis on aspirin desensitization and continuous treatment with aspirin.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE